Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syrian territory used by the IS group, as stated by the UK's MoD.
The location, located using reconnaissance, was thought to be storing arms and explosives, the release indicated, and was situated in mountainous terrain just above the ancient city of Palmyra in Syria's central region.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a series of access tunnels providing entry to the site... early reports indicate the strike was effective," the ministry announced.
There was no sign of any harm to civilians in the operation conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as ISIS - enforced extremist governance over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This operation underscores the UK's leading role, and commitment to work closely with our partners, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister stated.
British military aircraft have conducted patrols over Syria to "prevent any attempted comeback" of Islamic State subsequent to its routing at the Baghuz confrontation in 2019, the authorities noted.
"I must thank every member of the UK armed forces participating in this operation for their expertise and their valour," the Defence Secretary said. "They were among thousands of British personnel on duty over the holidays. This mission, to take out terrorist threats who threaten our safety, shows how UK forces are always on standby, throughout the year, ensuring Britain's security within its borders and strong abroad."
In December, the American forces executed what it described as a "massive strike" on Daesh sites in the country, after an attack resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The United Nations estimates Islamic State still has between 5,000 and 7,000 fighters in Syria and Iraq.